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HAPPINESS; AN OUTCOME OF CHEMISTRY


HAPPINESS; AN OUTCOME OF CHEMISTRY
PROF WAQAR HUSSAIN
              
                       
        George William Curtis once said: “Happiness lies, first of all, in health”. He was right as there are about seven chemicals, If not more, teeming in healthy individuals and are responsible for mode elevation, feeling of well being, pain reliever, love accelerator, emotional wellness and ultimately blossom into attractive, colourful, fabulous and eye catching bouquet  of flowers; emanating fragrance, aroma and cologne of  gladness, cheerfulness and happiness. These seeds of merriment are serotonin, dopamine, endorphin, estrogens, testosterones, vitamins and minerals, this rainbow of seven chemicals elevate man’s body, mind and soul up to the seventh tiers of the sky. So, happiness is nothing but the manifestation of the effects of these chemicals.
                1st, Serotonin is a monoamine neurotransmitter derived from tryptophan (an amino acid) primarily found in gastrointestinal tract, platelets and central nervous system of man. About 90% of human’s total serotonin originates from intestinal wall, and then it goes to blood and is engulfed by platelets for storage.
                Serotonin is unanimously believed to be contributor of feeling of well being and happiness. Serotonin also regulates gut movement, ageing, learning and memory. The good sources of serotonin are banana, dates and papayas. Serotonin level slides downward but in later stage of ageing.

                Serotonin acts as an antidepressant and a person, with high ratio, has a positive, optimistic and buoyant image of the world. Its production level depends upon genetic disposition as some produces more other less.  So our 28 feet long coiled chord of intestine is the magma which when erupt, fills our lives with happiness.
                2nd, Dopamine is also a neurotransmitter released in brain by nerve cells. It is a pacemaker; too much of it make one restless and too little makes one slow. Moderate level works well and brings body comfort and ultimately bliss of mind. It plays a vital role in reward-moderated behaviour. Every type of reward enhances its level in the brain. Some addictive drugs like cocaine, amphetamine and methamphetamine amplify the effect of dopamine. Several diseases of nervous system are correlated with malfunction of dopamine system. Parkinson’s disease (a disease that causes trembling of the arms and legs and muscular rigidity) is the outcome of loss of dopamine-secreting neuron in mid brain area. It is also believed that schizophrenia (a mental disease marked by disconnection between thoughts and actions, frequently with delusion and retreat from social life) involves altered level of dopamine activity and there is increased sensitivity of dopamine receptors in the frontal cortex.
               3rd, Endorphin, a neurotransmitter, is a polypeptide that binds to pain receptors and thus block pain sensation and painless condition is always a comfort of body and mind. It in acronym: endo stands for endogenous and orphin came from morphine. Morpheus Greek god of sleep as morphine like substance, originating from within the body, brings soothing feeling. It is secreted by pituitary gland, capable of relieving pain in manner similar to that of morphine.
               Endorphin, along with pain reducing property, is also connected with euphoric condition of feeling, appetite modulation and the release of sex hormones. So the end result is fain and fabulous feeling. Prolonged and continuous exercise contributes to increased production of endorphin.

 About 30 minutes of exercise will increase endorphin secretion five times. They are also produced during excitement, pain, consumption of spicy food, love and orgasm and bring emotional wellness. Chinese insert acupuncture needle at a specific body point to trigger production of endorphins.
                


 4th, Estrogens are steroid, secreted by ovaries, responsible for development female reproductive system and secondary sex characteristics. The famous Urdu poet Iqbal said: “wajood e zann sa ha qainat main rang” (the beautiful colour of universe are the result of the existence of females).Further, sex drive depends on estrogen and makes the mood pleasant and loving. Estrogens are present in both men and women. The scarcity of estrogens in female produces a wide range of physiological disorder and abnormal irritable mood swing. Estrogens level can be increased by taking estrogen rich food like meat, barley, dates, eggs, garlic, soybean, wheat and outer covering of cereals and pulses etc.
                 5th, Testosterones are a steroidal hormone secreted by testicles of male and the ovaries of female. It is the principle male hormone, responsible for development of male reproductive system and secondary sex characteristics.
       It has been found that when testosterone and endorphins in ejaculated semen meet the cervical wall after sexual intercourse, females receive a spike in testosterone, endorphin and oxytocin(a hormone secreted by pituitary gland involved in contraction of alveoli of mammary glands during expression of milk and in promoting smooth muscle contraction of uterus during coitus and during parturition) levels and males after orgasm during copulation experience an increase in endorphin and a marked increase in oxytocin levels. This adds to the hospitable physiological environment in the female internal reproductive tract for conceiving, and latter for nurturing the conception in the pre-embryonic stages and stimulate feeling of love, desire and paternal care in the male.
                Hypogonadism(low testosterone level or defect of reproductive system due to lack of function of gonads(testes or ovaries) causes depression, fatigue , irritability, mood swing , loss of concentration, decrease in libido, weight gain, breast tissue development in male, hair loss , poor work performance, osteoporosis, increase risk of heart attack and decrease male life expectancy.
                   Factors which lower testosterones level include obesity, stress, hypertension, high cholesterol, less sleep, intoxication, ageing (after the age of 40, testosterones level drop roughly one percent per year. one cannot do much about it).
                 On the other hand, factors which can enhance testosterones level are:
(1)  Men who take more magnesium are likely to have a higher amount of free testosterone in their bodies. Magnesium is found in fiber rich cereals, spinach, nuts, beans, etc.
(2) A high protein (especially albumin) intake increases the amount of bio-available testosterone.
(3) Zinc inhibit aromatase enzyme that converts testosterone into estrogen. The recommended dose for inhibiting aromatize is 80 mg daily.
(4) Vitamin-C suppresses the release of the stress hormone cortisol which decreases testosterone level. So, less cortisol, more testosterone.
            6th and 7th are vitamins and minerals. Vitamins are accessory organic food factors present in many food stuffs and essential for normal growth and nutrition of a man. There are about 32 different vitamins, however, famous one are A, B, C, E, D, K. Dietary minerals are chemicals required by living organism, other than the four elements Carbon, Hydrogen, Nitrogen, and Oxygen, present in common organic molecules. Over 20 dietary minerals are necessary for human.

              Both these micronutrients are essential for brain Chemistry because they are integral part of all the biochemical pathways which take to the manufacturing of the neurotransmitters which help to determine mood, delight and happiness.
                
Diet should contain all vitamins especially B, C and E. Egg yolk, cod liver oil, fruits, liver, beans, cereals and vegetables are rich sources of vitamins. Apart from vitamins, minerals are also very important like Zinc, Magnesium, Selenium, Molybdenum, Copper, Iron, Calcium, Sodium, Potassium, Phosphorous, Manganese, 
etc. Fruits and vegetables are rich source of minerals. A person can also take multi vitamin and multi mineral tablets. But it is believed by nutritionists that they are less efficacious in isolated form. So it is advisable to take them directly from fruits and vegetables.
                 Vitamins and minerals play a vital role in digestion of food, the transport and absorption of nutrients into the cells and the formation of the neuron transmitters. They play a vital regulatory role in the body metabolism leading to healthy brain and body and thus pave the way for a cheerful live.
                 In sum, these seven colours of spectrum, if blended properly, can be transformed into white glittering spark of happiness. On one hand, these are the gift of God but on the other hand man can manage them by taking proper diet, precautionary measure and proper exercise. It means some part of happiness lie in our hands with proper modus operandi blended with meditation to seek the Benediction, Blessing and BSSeatitude of God; it can fill our lives with plentiful happiness. All that required is our willingness, commitment, control and completion of planned strategy.
                           Thoreau has rightly said: “Man is artificer of his own happiness
References:
          WIKEPEDIA
          CHEMISTRY OF HAPPINESS (MODE STEPS)
           PENGUINE DICTIONARY OF BIOLOGY
          JOURNAL OF PHARMACEUTICAL AND BIOCHEMICAL ANALYSIS
         EVERY DAY SCIENCE BY IQBAL A BHATTI
         EVERY DAY SCIENCE BY DR M IKRAM KASHMIRI
         BOOK OF QUOTATIONS BY J D CHAUDHRI
    
                                     











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